H2A.Z (H2AFZ) Rabbit Polyclonal Antibody

CAT#: AP31903PU-N

H2A.Z (H2AFZ) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/100-1/5000.
  Immunohistochemistry: 1/100-1/200.

• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from internal part of Human Histone H2A.Z.
• Specificity: This antibody reacts with H2A/z.
• Formulation: 0.1M Tris, 0.1M Glycine, 2% Sucrose
  State: Purified
  State: Lyophilized powder
  Preservative: None
• Reconstitution Method: Restore in distilled water
• Concentration: lot specific
• Purification: Protein A Chromatography
• Conjugation: Unconjugated
• Storage:

  Lyophilized powder stable for a minimum of 2 years at -20°C.
  Store reconstituted antibody at 2-4°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: Six months from despatch.

• Gene Name: H2A histone family member Z
• Database Link:
  Entrez Gene 3015 Human
  UniProt ID P0C0S5
• Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Histone H2A.Z is a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
• Synonyms: H2AFZ, H2AZ, H2A/z