hnRNP A1 (HNRNPA1) Rabbit Polyclonal Antibody

CAT#: AP31870PU-N

hnRNP A1 (HNRNPA1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from 293/Jurkat/COLO205 cells, using hnRNP A1 Antibody. The lane on the right is treated with the synthesized peptide.

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  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of HeLa cells, using hnRNP A1 Antibody. The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/20000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from Human hnRNP A1.
  Epitope: aa 51-100.
• Specificity: This antibody detects endogenous levels of total hnRNP A1 protein.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 50% Glycerol
  State: Aff - Purified
  State: Liquid purified IgG fraction
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: heterogeneous nuclear ribonucleoprotein A1
• Database Link:
  Entrez Gene 3178 Human
  UniProt ID P09651
• Background: HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.
• Synonyms: HNRPA1, Heterogeneous nuclear ribonucleoprotein A1, hnRNP-A1