KCNN4 (227-239) Goat Polyclonal Antibody

CAT#: AP31012PU-N

KCNN4 (227-239) goat polyclonal antibody, Aff - Purified

Product Images

Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 - 7.5 µg/ml.
• Reactivities: Human, Bovine, Canine, Rabbit
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from positions 227-239 of human KCNN4 (NP_002241.1)
• Specificity: This antibody reacts to Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (Kcnn4) at aa 227-239.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: potassium calcium-activated channel subfamily N member 4
• Database Link:
  Entrez Gene 3783 Human
  UniProt ID O15554
• Background: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
• Synonyms: KCNN4, IK1, IKCA1, KCA4, SK4, KCa3.1, Putative Gardos channel
• Note: The Kcnn4 synonym, IK1, also is used to describe the cardiac inward rectifier current.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane