FH (176-189) Goat Polyclonal Antibody

CAT#: AP23828PU-N

FH (176-189) goat polyclonal antibody, Aff - Purified

Product Images

Antibody (0.01 ug/ml) staining of Human Kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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  Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/64000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
  Western Blot.
• Reactivities: Canine, Human, Mouse, Rat, Bovine, Chicken, Drosophila, Equine, Hamster, Insect, Monkey, Porcine, Sheep, Xenopus, Zebrafish
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human FH
• Specificity: This antibdoy reacts to the internal region of FH.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: fumarate hydratase
• Database Link:
  Entrez Gene 24368 RatEntrez Gene 14193 MouseEntrez Gene 2271 Human
  UniProt ID P07954
• Background: FH / Fumarase / MCL is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm.
• Synonyms: HLRCC, LRCC, MCL, MCUL1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Citrate cycle (TCA cycle), Metabolic pathways, Pathways in cancer, Renal cell carcinoma