Apolipoprotein A I (APOA1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23390PU-N

Apolipoprotein A I (APOA1) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot with APOA1 Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1 μg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human APOA1
• Specificity: This antibody detects Apolipoprotein A I (APO AI) (N-term). No cross reactivity with other proteins.
• Formulation: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05mg Thimerosal, 0.05 mg Sodium Azide
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: Restore in 0.2 ml distilled water to a concentration of 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: apolipoprotein A1
• Database Link:
  Entrez Gene 11806 MouseEntrez Gene 25081 RatEntrez Gene 335 Human
  UniProt ID P02647
• Background: Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.
• Synonyms: APOA1, ApoA-I, Apo-AI, ApoAI

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: PPAR signaling pathway