TIMP4 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23356PU-N

TIMP4 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of rat kidney tissue lysis using TIMP4 antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect TIMP-4 in cells and tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A peptide mapping at the C-terminal end of human TIMP-4
• Specificity: This antibody detects TIMP4 (C-term). No cross reactivity with other proteins.
• Formulation: 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 1.2% sodium acetate or neutral PBS. If 0.5ml of PBS is used, the antibody concentration will be 100μg/ml.
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: TIMP metallopeptidase inhibitor 4
• Database Link:
  Entrez Gene 110595 MouseEntrez Gene 680130 RatEntrez Gene 7079 Human
  UniProt ID Q99727
• Background: The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA.The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.
• Synonyms: TIMP-4, Tissue inhibitor of metalloproteinases 4, Metalloproteinase inhibitor 4

Reference Data

• Protein Families: Druggable Genome, Secreted Protein