ADAMTS4 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23310PU-N

ADAMTS4 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

ADAMTS4 Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1μg/ml.
• Reactivities: Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of mouse ADAMTS4
• Specificity: This antibody detects ADAMTS4 at C-term.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif 4
• Database Link:
  Entrez Gene 66015 RatEntrez Gene 240913 Mouse
  UniProt ID O75173
• Background: ADAM metallopeptidase with thrombospondin type 1 motif, 4, also known as ADAMTS4, is a human gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (adisintegrin and metalloprotease) family members based on the multiple copies of thrombospondin 1-like repeats they carry. Pratta et al. (2003) concluded that ADAMTS4 is constitutively produced in monolayer chondrocytes, capsular fibroblasts, and cartilage, and that stimulation by interleukin-1 results in aggrecanase activation. Thus, the activator could be a potential target by which to control aggrecanase-mediated degradation in arthritic diseases.
• Synonyms: ADAMTS-4, ADAM-TS4, Aggrecanase-1, ADMP1, ADMP-1, KIAA0688

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane