SPI1 (27-37) Goat Polyclonal Antibody

CAT#: AP22967PU-N

SPI1 (27-37) goat polyclonal antibody, Aff - Purified

Product Images

Colon, lymphoid aggregate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Human, Bovine, Canine, Equine, Porcine, Rabbit
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human SPI1 / PU.1 (NP_001074016.1; NP_003111.2)
• Specificity: This antibody reacts to the internal region of Spi-1 Proto-oncogene (SPI1).
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA and 0.02% sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Spi-1 proto-oncogene
• Database Link:
  Entrez Gene 6688 Human
  UniProt ID P17947
• Background: Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.
• Synonyms: Transcription factor PU.1, SPI-1 proto-oncogene, SFPI1

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer