PCK1 (513-524) Goat Polyclonal Antibody

CAT#: AP22519PU-N

PCK1 (513-524) goat polyclonal antibody, Aff - Purified

Product Images

Human Kidney (formalin-fixed, paraffin-embedded) stained with PCK1 antibody at 2 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Liver (formalin-fixed, paraffin-embedded) stained with PCK1 antibody at 2 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/8000.
  Immunohistochemistry on Paraffin Sections: 2 µg/ml.
• Reactivities: Canine, Human, Mouse, Rat, Bat, Equine, Monkey, Rabbit
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human PCK1
• Specificity: This antibody detects PCK1 / PEPCK1 at aa 513-524.
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: phosphoenolpyruvate carboxykinase 1
• Database Link:
  Entrez Gene 18534 MouseEntrez Gene 362282 RatEntrez Gene 696207 MonkeyEntrez Gene 5105 Human
  UniProt ID P35558
• Background: PCK1 is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency.
• Synonyms: PEPCK-C, PEPCKC, Phosphoenolpyruvate carboxylase, PEP carboxykinase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Insulin signaling pathway, Metabolic pathways, PPAR signaling pathway, Pyruvate metabolism