beta Catenin (CTNNB1) Rabbit Polyclonal Antibody

CAT#: AP21100PU-N

beta Catenin (CTNNB1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Catenin-beta antibody (Cat.-No.: AP21100PU-N) in extracts from 293 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Catenin-beta protein.
  (region surrounding Gln482)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 92 kDa
• Gene Name: catenin beta 1
• Database Link:
  Entrez Gene 12387 MouseEntrez Gene 84353 RatEntrez Gene 1499 Human
  UniProt ID P35222
• Background: The catenins, alpha, beta and gamma, are proteins which bind to the highly conserved,intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. alpha-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin has also been found in complexes with the tumor suppressor protein APC. gamma-catenin, also known as plakoglobin, is a protein that binds with alpha-catenin and N-cadherin. It has been shown thatthe transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.
• Synonyms: CTNNB1, CTNNB, Beta-catenin

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
• Protein Pathways: Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway