67kDa Laminin Receptor (RPSA) Rabbit Polyclonal Antibody

CAT#: AP20782PU-N

67kDa Laminin Receptor (RPSA) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of Laminin-R antibody (Cat.-No.: AP20782PU-N) in extracts from K562 cells.

• 

  Immunohistochemistry (IHC) analyzes of Laminin-R antibody (Cat.-No.: AP20782PU-N) in paraffin-embedded human tonsil tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Laminin-R protein.
  (region surrounding Gln215)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 40 kDa
• Gene Name: ribosomal protein SA
• Database Link:
  Entrez Gene 16785 MouseEntrez Gene 29236 RatEntrez Gene 3921 Human
  UniProt ID P08865
• Background: Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma Laminin-binding protein) is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Addi-tionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.
• Synonyms: 40S ribosomal protein SA, LAMBR, LAMR1, LamR, Laminin receptor 1, 37LRP, LRP/LR, 67LR, NEM/1CHD4

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Ribosome