Mitofusin 2 (MFN2) Rabbit Polyclonal Antibody

CAT#: AP20775PU-N

Mitofusin 2 (MFN2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Mfn2 antibody (Cat.-No.: AP20775PU-N) in extracts from HuvEc cells.

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  Immunohistochemistry (IHC) analyzes of Mfn2 antibody (Cat.-No.: AP20775PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Mfn2 protein.
  (region surrounding Phe403)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 86 kDa
• Gene Name: mitofusin 2
• Database Link:
  Entrez Gene 64476 RatEntrez Gene 170731 MouseEntrez Gene 9927 Human
  UniProt ID O95140
• Background: MFN2 is an essential transmembrane GTPase which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton, plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 lead to Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.
• Synonyms: MFN2, CPRP1, KIAA0214

Reference Data

• Protein Families: Transmembrane