DOK1 Rabbit Polyclonal Antibody

CAT#: AP20744PU-N

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DOK1 rabbit polyclonal antibody, Aff - Purified

Product Datasheet for 'AP20744PU-N'

USD 370.00

2 Weeks

    • 100 ug

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Product Data
Applications IF, IHC, WB
Recommended Dilution Western blot: 1/500 - 1/1000.
Immunohistochemistry on paraffin sections: 1/50 - 1/200.
Immunofluorescence: 1/50 - 1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Dok-1 protein.
(region surrounding Pro356)
Formulation Phosphate buffered saline (PBS), pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
Concentration 1.0 mg/ml
Purification Affinity chromatography (> 95% (by SDS-PAGE)
Predicted Protein Size ~ 62 kDa
Gene Name Homo sapiens docking protein 1 (DOK1), transcript variant 1
Background Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.
Synonyms Docking protein 1, pp62, p62(dok)
Reference Data
Protein Families Druggable Genome
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