DOK1 Rabbit Polyclonal Antibody
DOK1 rabbit polyclonal antibody, Aff - Purified
|Applications||IF, IHC, WB|
|Recommended Dilution||Western blot: 1/500 - 1/1000.
Immunohistochemistry on paraffin sections: 1/50 - 1/200.
Immunofluorescence: 1/50 - 1/200.
|Reactivity||Human, Mouse, Rat|
|Specificity||This antibody detects endogenous levels of Dok-1 protein.
(region surrounding Pro356)
|Formulation||Phosphate buffered saline (PBS), pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
|Purification||Affinity chromatography (> 95% (by SDS-PAGE)|
|Predicted Protein Size||~ 62 kDa|
|Gene Name||Homo sapiens docking protein 1 (DOK1), transcript variant 1|
|Background||Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.|
|Synonyms||Docking protein 1, pp62, p62(dok)|
|Protein Families||Druggable Genome|