HDAC6 Rabbit Polyclonal Antibody

CAT#: AP20236PU-N

HDAC6 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of HDAC6 antibody (AP20236PU-N) in extracts from HepG2 cells.

• 

  Immunohistochemistry analyzes of HDAC6 antibody (AP20236PU-N) in paraffin-embedded human testis tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of HDAC6 protein.
• Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~131 kDa
• Gene Name: histone deacetylase 6
• Database Link:
  Entrez Gene 15185 MouseEntrez Gene 10013 Human
  UniProt ID Q9UBN7
• Background: HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.
• Synonyms: Histone deacetylase 6, HD6, KIAA0901, JM21

Reference Data

• Protein Families: Druggable Genome, Transcription Factors