PSME2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP17686PU-N

PSME2 (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of PSME2 antibody (C-term) in mouse lung tissue lysates (35ug/lane). PSME2 (arrow) was detected using the purified Pab.

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  Formalin-fixed and paraffin-embedded mouse hepatocarcinoma reacted with PSME2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
  Immunohistochemistry on Paraffin embedded sections 1/50 - 1/100
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human PSME2
• Specificity: This antibody reacts to PSME2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: proteasome activator subunit 2
• Database Link:
  Entrez Gene 19188 MouseEntrez Gene 5721 Human
  UniProt ID Q9UL46
• Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME2 is the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon.
• Synonyms: Proteasome activator, PA28b, PA28beta

Reference Data

• Protein Pathways: Antigen processing and presentation, Proteasome