MTBP (C-term) Rabbit Polyclonal Antibody

CAT#: AP17569PU-N

MTBP (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of MTBP antibody (C-term) in K562 cell line lysates (35ug/lane). MTBP (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human MTBP
• Specificity: This antibody reacts to MTBP.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: MDM2 binding protein
• Database Link:
  Entrez Gene 27085 Human
  UniProt ID Q96DY7
• Background: MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.
• Synonyms: Mdm2-binding protein, hMTBP, Mdm2