ITPKA (C-term) Rabbit Polyclonal Antibody

CAT#: AP15175PU-N

ITPKA (C-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of ITPKA Antibody (C-term) in K562 cell line and mouse lung tissue lysates (35ug/lane). ITPKA (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Peptide ELISA: 1/1000.
  Western Blot: 1/1000.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 345~375 amino acids from the C-terminal region of human ITPKA
• Specificity: This antibody recognizes Human and Mouse ITPKA at C-term.
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: inositol-trisphosphate 3-kinase A
• Database Link:
  Entrez Gene 3706 Human
  UniProt ID P23677
• Background: ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.
• Synonyms: IP3KA, InsP 3-kinase A