c-Myc (MYC) pThr58 Rabbit Polyclonal Antibody
Other products for "MYC"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1/1,000. Dot Blot: 1/100-1/500. Western Blot: 1/50-1/200. |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T58 of human MYC. |
Specificity | This antibody detects MYC pThr58. Predicted to cross react with Mouse and Zebrafish (100% Antigen Homology). |
Formulation | PBS with 0.09% (W/V) Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Purification | Protein A Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | v-myc avian myelocytomatosis viral oncogene homolog |
Database Link | |
Background | MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. |
Synonyms | Transcription factor p64, BHLHE39 |
Note | Molecular weight: 50434 Da |
Reference Data |
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