CFTR Rabbit Polyclonal Antibody
Other products for "CFTR"
Specifications
Product Data | |
Applications | ELISA, IF, IP, WB |
Recommended Dilution | ELISA: 1/2000-1/32000. Western Blot: 1/500-1/1000. Immunofluorescence. Immunoprecipitation. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptides derived from C-terminal domain of Human CFTR protein |
Specificity | This antibody reacts with human 168 kDa CFTR. |
Formulation | Tris 0,1M, glycine 0,1M, sucrose 2% State: Serum State: Lyophilized serum Preservative: None |
Reconstitution Method | Restore in distilled water. |
Conjugation | Unconjugated |
Storage | Prior to reconstitution store the antibody at -20°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | cystic fibrosis transmembrane conductance regulator |
Database Link | |
Background | CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. |
Synonyms | Cystic fibrosis transmembrane conductance regulator |
Reference Data |
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