Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody

CAT#: AP07652PU-N

Angiotensin Converting Enzyme 2 (ACE2) rabbit polyclonal antibody, Aff - Purified

Product Images

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Kidney.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within aa 180-230 of ACE2.
• Specificity: This antibody reacts with a peptide corresponding to amino acids near the center of ACE2.
• Formulation: PBS containing 0.02% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: angiotensin I converting enzyme 2
• Database Link:
  Entrez Gene 59272 Human
  UniProt ID Q9BYF1
• Background: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology . In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
• Synonyms: Angiotensin-converting enzyme 2
• Note: Family: Protease.
  Subfamily: Metallopeptidase M2.