TNFRSF14 Rabbit Polyclonal Antibody

CAT#: AP07375PU-N

TNFRSF14 rabbit polyclonal antibody, Aff - Purified

Product Images

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 2 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide
• Specificity: This antibody reacts to a 16 amino acid peptide from near the carboxy terminus of TNFRSF14.
• Formulation: Phosphate buffered saline, containing 0.02% sodium azide
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: tumor necrosis factor receptor superfamily member 14
• Database Link:
  Entrez Gene 8764 Human
  UniProt ID Q92956
• Background: HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes). Binding by HVEM of the ligand LIGHT induces receptor down regulation. Degradation or release of LIGHT by matrix metalloproteinases then contributes to the return to baseline levels for both LIGHT and HVEM.
• Synonyms: HVEA, Herpesvirus entry mediator A, TR2