SARM (SARM1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP07256PU-N

SARM (SARM1) (C-term) rabbit polyclonal antibody, Purified

Product Images

SARM1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Tonsil at 2 ug/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunocytochemistry: 2 µg/ml.
  Immunofluorescence: 2 µg/ml.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids near the C-terminus of Human SARM
• Specificity: This antibody is specific to a peptide corresponding to amino acids near the C-terminus of SARM.
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: sterile alpha and TIR motif containing 1
• Database Link:
  Entrez Gene 23098 Human
  UniProt ID Q6SZW1
• Background: Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.
• Synonyms: SARM, SAMD2, KIAA0524