Cytochrome P450 2A6 (CYP2A6) Rabbit Polyclonal Antibody

CAT#: AP06774PU-N

Cytochrome P450 2A6 (CYP2A6) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of CYP2A6 antibody in extracts from Jurkat cells.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 101-150 of Human CYP2A6.
• Specificity: This antibody detects endogenous levels of CYP2A6 protein.
  (region surrounding Glu131)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 56 kDa
• Gene Name: cytochrome P450 family 2 subfamily A member 6
• Database Link:
  Entrez Gene 1548 Human
  UniProt ID P11509
• Background: The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity.Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl is-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is involved in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication.
• Synonyms: CYP2A3,Cytochrome P450 2A6, CYPIIA6, CYPIIA3

Reference Data

• Protein Families: Druggable Genome, P450, Transmembrane
• Protein Pathways: Caffeine metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Retinol metabolism