alpha Synuclein (SNCA) Rabbit Polyclonal Antibody

CAT#: AP06582PU-N

alpha Synuclein (SNCA) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry (IHC) analyzes of SNCA antibody in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Synuclein-α.
• Specificity: This antibody detects endogenous levels of SNCA protein.
  (region surrounding Glu123)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 18 kDa
• Gene Name: synuclein alpha
• Database Link:
  Entrez Gene 6622 Human
  UniProt ID P37840
• Background: The synuclein family members, including alpha-synuclein (also designated NACP for non-beta amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. alpha-synuclein is localized to neuronal cell bodies and synapses. alpha-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation alpha-synuclein was found to be up-regulated, while beta-synuclein is down-regulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of alpha-synuclein has been found in patients with early onset Parkinson’s disease.
• Synonyms: NACP, PARK1