Sumo 1 (SUMO1) Rabbit Polyclonal Antibody
Other products for "SUMO1"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. Immunofluorescence: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of Sumo1 protein. (region surrounding Ser2) |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 12 kDa |
Gene Name | small ubiquitin-like modifier 1 |
Database Link | |
Background | The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2, and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. The unconjugated SUMO-1, 2, and 3 proteins are approximately 11 kDa in mass and localize to the nuclear membrane, nuclear bodies, and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IκBα, MDM2, p53, PML, and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates Amyloid β generation and may be critical in the onset or progression of Alzheimer’s disease. |
Synonyms | SMT3C, SMT3H3, UBL1, GMP1, SMT3 homolog 3, Sentrin |
Reference Data |
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