beta Catenin (CTNNB1) Rabbit Polyclonal Antibody

CAT#: AP06038PU-N

beta Catenin (CTNNB1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in extracts from SW626 cell using Catenin-β antibody.

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  Immunohistochemistry (IHC) analysis of Catenin-β antibody on paraffin-embedded sections.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human Catenin-β.
• Specificity: This antibody detects endogenous levels of Catenin-β protein (region surrounding Ile35).
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: ~ 92 kDa
• Gene Name: catenin beta 1
• Database Link:
  Entrez Gene 1499 Human
  UniProt ID P35222
• Background: The catenins, α, β and γ, are proteins which bind to the highly conserved,intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, is a protein that binds with α-catenin and N-cadherin. It has been shown thatthe transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.
• Synonyms: CTNNB1, CTNNB, Beta-catenin