IL23 (IL23A) (C-term) Rabbit Polyclonal Antibody

CAT#: AP05588PU-N

IL23 (IL23A) (C-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of whole cell lysate form Raji, human Burkitt's lymphoma derived cells probed with Rabbit anti Human Interleukin-23 in the absence (A) or presence (B) of blocking peptide

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  Immunocytochemical staining of Raji cells with Rabbit anti Human interleukin-23

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1-2 µg/ml. Detects a band of approximately 24kDa in Raji cell lysates.
  Immunocytochemistry.
  Immunohistochemistry on Frozen Sections: 10 µg/ml.
  Positive control tissue: Raji cells.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A 14 amino acid peptide from near the carboxy-terminus of human IL-23
• Specificity: This antibody detects an epitope within the C-terminal (CT) domain of Human Interleukin-23 (IL-23).
• Formulation: Phosphate buffered saline (PBS)
  State: Purified
  State: Liquid purified IgG fractioon
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 23 subunit alpha
• Database Link:
  Entrez Gene 83430 MouseEntrez Gene 51561 Human
  UniProt ID Q9NPF7
• Background: IL23 is a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.
  IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.
• Synonyms: IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway