ELOVL4 Rabbit Polyclonal Antibody

CAT#: AP05307PU-N

ELOVL4 rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot (1:400 starting dilution).
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptdide derived from the human ELOV4 protein
• Specificity: This antibody detects ELOV4, expressed in the retina and at much lower level in the brain.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: ELOVL fatty acid elongase 4
• Database Link:
  Entrez Gene 6785 Human
  UniProt ID Q9GZR5
• Background: Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. Elovl4 is expressed in the retina and only a limited number of mammalian other tissues, including skin, with unknown function. In a mouse model with the 5-bp deletion in the Elovl4 gene, mice in the heterozygous state (Elovl4(+/del)) demonstrate progressive photoreceptor degeneration. Homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Lipid analyses of epidermis from Elovl4(del/del) mice show a decrease in very long-chain fatty acids (VLFAs) in both the ceramide/glucosylceramide and the free fatty-acid fractions. ELOVL4 is required for generating VLFA critical for epidermal barrier function.
• Synonyms: ADMD; FLJ17667; FLJ92876; STGD2; STGD3

Reference Data

• Protein Families: Transmembrane