Eph receptor B1 (EPHB1) (Cytopl. Dom.) Sheep Polyclonal Antibody

CAT#: AP05062PU-N

Eph receptor B1 (EPHB1) (Cytopl. Dom.) sheep polyclonal antibody, Purified

Product Images

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Specifications

Product Data

• Applications: IP
• Recommended Dilution: Western Blot: 1 - 10 µg/ml.
  Immunoprecipitation: 10 - 20 µg/ml.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A GST fusion protein ephB1 (Elk receptor) - CY corresponding to amino
• Specificity: This antibody reacts to ephB1 (Elk receptor) - CY.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig (0.2µm sterile filtered)
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch
• Gene Name: EPH receptor B1
• Database Link:
  Entrez Gene 2047 Human
  UniProt ID P54762
• Background: The immunogen used for the anti-human ephB1 (Elk receptor) - cytoplasmic(CY) region was a GST fusion protein ephB1 (Elk receptor) - CY corresponding to amino acid sequence 586 - 984 of the C terminus region and having a molecular weight of 116 kDa. EphB1, previously known as Elk (eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. EphB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. EphB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cell-cell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.
• Synonyms: EPHT2, NET, HEK6, ELK, EPH2, Ephrin type-B receptor 1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Axon guidance