GRB2 (198-217) Rabbit Polyclonal Antibody

CAT#: AP03043PU-N

GRB2 (198-217) rabbit polyclonal antibody, Aff - Purified

Product Images

Western Blotting analysis (reducing conditions) of Ramos cell lysate using two batches of rabbit anti-Grb2 polyclonal (A, B).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-2 μg/ml, reducing conditions.
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217)
• Specificity: This antibody recognizes Grb2, a highly conserved approximately 26 kDa adaptor protein.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: growth factor receptor bound protein 2
• Database Link:
  Entrez Gene 2885 Human
  UniProt ID P62993
• Background: Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
• Synonyms: Growth factor receptor-bound protein 2