Paxillin (PXN) Rabbit Polyclonal Antibody
Other products for "PXN"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 1:500-1:1000. IHC: 1:50-1:100. |
Reactivities | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthesized non-phosphopeptide derived from human Paxillin around the phosphorylation site of tyrosine 118 |
Specificity | This antibody detects endogenous levels of total Paxillin protein. |
Formulation | Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Affinity-chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | paxillin |
Database Link | |
Background | Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk). |
Synonyms | FLJ16691 |
Reference Data |
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