CACNA1H Rabbit Polyclonal Antibody

CAT#: AP01505PU-N

CACNA1H rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of T-type Ca++ CP aH antibody in extracts from A549 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 461-510 of Human T-type Ca++ CP α1H.
• Specificity: This antibody detects endogenous levels of T-type Ca⁺⁺ CP α1H protein. (region surrounding Pro492)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~259 kDa
• Gene Name: calcium voltage-gated channel subunit alpha1 H
• Database Link:
  Entrez Gene 8912 Human
  UniProt ID O95180
• Background: Voltage-dependent Ca⁺⁺ channels mediate Ca⁺⁺ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca⁺⁺-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an α1 subunit, an intracellular β subunit, a disulfide linked α2/δ subunit and a transmembrane γ subunit. Ca⁺⁺ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca⁺⁺ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca⁺⁺ current types. T-type Ca⁺⁺ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).
• Synonyms: Cav3.2