PPP1R3C Rabbit Polyclonal Antibody

CAT#: AP01499PU-N

PPP1R3C rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of PTG antibody (Cat.-No.: AP01499PU-N) in extracts from HepG2 cells.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of PTG protein. (region surrounding Lys75)
• Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~36 kDa
• Gene Name: protein phosphatase 1 regulatory subunit 3C
• Database Link:
  Entrez Gene 5507 Human
  UniProt ID Q9UQK1
• Background: Protein phosphatase 1 (PP1) is a serine-threonine protein phosphatase that plays a central role in mediating the effects of insulin on glucose and lipid metabolism. PTG (protein targeting to glycogen) was cloned from 3T3-L1 adipocytes as a protein that binds to the PP1 catalytic subunit. The human homolog of PTG, designated PPP1R5, has been shown to bind to PP1 and to modulate its specificity. PTEN/PPP1R5 shows 42% identity to the glycogen binding subunit, G(L), of rat liver PP1. PTG is expressed predominantly in insulin-sensitive tissues, and it localizes PP1 to glycogen. PTG also has been shown to interact with several enzymes involved in the hormonal regulation of glycogen metabolism, including phosphorylase kinase, phosphorylase A and glycogen synthase. These data indicate a role for PTG in glycogen metabolism, possibly that of a molecular scaffold.
• Synonyms: PPP1R5