CHURC1-FNTB Rabbit Polyclonal Antibody
Other products for "FNTB"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western Blot: 1/500-1/1000. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | FTβ antibody detects endogenous levels of FTβ protein. (region surrounding Glu285) |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 50 kDa |
Gene Name | CHURC1-FNTB readthrough |
Database Link | |
Background | Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an α-β heterodimer. The β subunit binds the peptide substrate while the α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate. The α subunit is shared with a second prenyl transferase, geranyl-geranyl transferase, that attaches 20 carbon geranylgeranyl to Ras related proteins that terminate in a Cys-A-A-Xaa recognition site in which Xaa is leucine. |
Synonyms | FTase-beta, CAAX farnesyltransferase subunit beta |
Reference Data |
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