PGP9.5 (UCHL1) Mouse Monoclonal Antibody [Clone ID: SPM575]

CAT#: AM50185PU-S

PGP9.5 (UCHL1) mouse monoclonal antibody, clone SPM575, Purified

Specifications

Product Data

• Clone Name: SPM575
• Applications: IF, IHC, WB
• Recommended Dilution: ELISA: Use BSA free Antibody for coating.
  Western Blotting: 0.5-1 µg/ml.
  
  Immunofluorescence: 1-2 µg/ml.
  Immunohistochemistry on Frozen Sections: 0.5-1 µg/ml for 30 minutes at RT.
  Positive Control: Cerebellum.
• Reactivities: Bovine, Canine, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep, Zebrafish
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Native UchL1 (PGP9.5) protein from brain.
• Specificity: This Monoclonal Antibody reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1).
  Cellular Localization: Cytoplasmic
• Formulation: 10mM PBS
  State: Purified
  State: Liquid purified IgG fraction from Bioreactor Concentrate
  Stabilizer: 0.05% BSA
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Purification: Protein A/G Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 20-30 kDa
• Gene Name: ubiquitin C-terminal hydrolase L1
• Database Link:
  Entrez Gene 7345 Human
  UniProt ID P09936
• Background: PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
• Synonyms: UCH-L1, PGP 9.5, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5