VEGFC Mouse Monoclonal Antibody [Clone ID: 107/A11]

CAT#: AM33410PU-N

VEGFC mouse monoclonal antibody, clone 107/A11, Purified

Product Images

VEGF-C Sandwich-ELISA using recombinant human VEGF-C as standard ). Mouse anti-human VEGF-C Antibody AM33409PU-N (Clone 9/G10) was used as capture antibody, Biotinylated Mouse anti-Human VEGF-C Antibody AM33410BT-N (Clone 107/A11) was used for detection.

Specifications

Product Data

• Clone Name: 107/A11
• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1-5 µg/ml.
  Western blot: 1-5 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Human VEGF-C (Cat.-No AR01001PU-N)
• Specificity: This antibody recognizes Human VEGF-C.
  Other species not tested.
• Formulation: PBS
  State: Purified
  State: Lyophilized purified IgG fraction
  Stabilizer: None
• Reconstitution Method: Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
• Purification: Protein G Chromatography
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: vascular endothelial growth factor C
• Database Link:
  Entrez Gene 7424 Human
  UniProt ID P49767
• Background: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.
• Synonyms: VEGFC, VRP, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, Flt4 ligand