PTP rho (PTPRT) Mouse Monoclonal Antibody [Clone ID: 3D7]

CAT#: AM33020PU-N

PTP rho (PTPRT) mouse monoclonal antibody, clone 3D7, Purified

Specifications

Product Data

• Clone Name: 3D7
• Applications: FC, IF, IP, WB
• Recommended Dilution: Western blot.
  Immunoprecipitation.
  Immunofluorescence.
  Flow Cytometry.
• Reactivities: Human, Porcine, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: This antibody has been derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads.
  The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPµ molecule (aa 1-742), fused COOH terminally to GST.
• Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed against the extracellular domain of RPTPµ.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: protein tyrosine phosphatase, receptor type T
• Database Link:
  Entrez Gene 11122 Human
  UniProt ID O14522
• Background: Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substrates. RPTPµ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions.
  Intracellularly, RPTPµ consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPµ is catalytically active, whereas its second (C-terminal) domain is inactive. RPTPµ is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
• Synonyms: PTP rho, RPTP-rho, R-PTP-T, KIAA0283