Staphylococcus aureus Enterotoxin B Mouse Monoclonal Antibody [Clone ID: SEB]

CAT#: AM32962PU-N

Staphylococcus aureus Enterotoxin B mouse monoclonal antibody, clone SEB, Purified

Specifications

Product Data

• Clone Name: SEB
• Applications: ELISA
• Recommended Dilution: ELISA.
  This Staphylococcal Enterotoxin B (Clone SEB) as a superantigen for T-lymphocytes is a potential targeting antigen in cancer immunotherapy. It has been suggested that monoclonal antibody to SEB has been useful in immunotherapy research.
• Reactivities: Staphylococcus aureus
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: SEB purified from Staphylococcus aureus.
• Specificity: Staphylococcal Enterotoxin B (SEB).
• Formulation: 0.01M PBS, pH 7.2 without preservatives
  State: Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Prior to reconstitution store at 2-8°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  UniProt ID P01552
• Background: Staphylococcal enterotoxin B (SEB) is an enterotoxin secreted by Staphylococcus aureus. The bacterium thrives on meet, baking and dairy products and also colonizes in host nasal passageway. Ingestion of SEB contaminated food is the common cause of “food poisoning”, manifested by flu-like symptoms, vomiting, diarrhea and intestinal cramps. In severe cases, SEB can cause respiratory failure and systemic toxic shock. These symptoms are the results of increased membrane permeability and abnormal activation of Tlymphocytes by SEB. SEB acts as a superantigen by binding directly to major histocompatibility complex class II (MHCII) on antigen presenting cells, thus, causing massive CD4 and CD8 Tcells activation and cytokine production. If unchecked, the process can result in systemic organ failure and death.
• Synonyms: SEB, entB, S. aureus