Pepsinogen II (PGC) Mouse Monoclonal Antibody [Clone ID: L10CC10]

CAT#: AM32098PU-N

Pepsinogen II (PGC) mouse monoclonal antibody, clone L10CC10, Ig Fraction

Specifications

Product Data

• Clone Name: L10CC10
• Applications: ELISA, IHC, WB
• Recommended Dilution: Western blotting
  Enzyme Immunoassays.
  Immunohistochemistry on Paraffin Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Pepsinogen II purified from Human tissue.
  Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
• Specificity: The antibody clone L10CC10 is specific to Human Pepsinogen II and has no crossreactivity to Human Pepsinogen I.
• Formulation: PBS
  State: Ig Fraction
  State: Liquid Ig fraction
  Stabilizer: 1.0% BSA
  Preservative: 0.09 % Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: progastricsin (pepsinogen C)
• Database Link:
  Entrez Gene 5225 Human
  UniProt ID P20142
• Background: Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and “pyloric” in differentiation (so called pseudopyloric metaplasia).
• Synonyms: Pepsinogen C, Progastricsin, Gastricsin, PGC