CD2 Mouse Monoclonal Antibody [Clone ID: B-E2]

CAT#: AM31181BT-N

CD2 mouse monoclonal antibody, clone B-E2, Biotin

Product Images

A typical staining pattern with the B-E2 monoclonal antibody of lymphocytes.

Specifications

Product Data

• Clone Name: B-E2
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: Use 10 µl to label 10⁶ cells or 100 µl of whole blood.
  Immunohistochemistry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Human thymocytes.
  Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells
• Specificity: Recognizes the Lymphocyte Function associated Antigen-2 (LFA-2), a 50 kDa protein.
• Formulation: PBS containing 5% BSA as stabilizer and 0.09% Sodium Azide as preservative
  Label: Biotin
  State: Lyophilized purified IgG fracgtion.
• Reconstitution Method: Restore with 1.0 ml deionised water.
• Purification: Ion Exchange Chromatography.
• Conjugation: Biotin
• Storage: Prior to reconstitution store at 2-8°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD2 molecule
• Database Link:
  Entrez Gene 914 Human
  UniProt ID P06729
• Background: CD2 which is also known as E-rosette receptor, T11 and lymphocyte-function antigen-2 (LFA-2) is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 (LFA-3), and CD15s (Sialyl Lewis X). p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 play a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
• Synonyms: SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Hematopoietic cell lineage