Amyloid beta (N-term) Mouse Monoclonal Antibody [Clone ID: NT 3F5]
CAT#: AM26395PU-L
Amyloid beta (N-term) mouse monoclonal antibody, clone NT 3F5, Aff - Purified
Specifications
Product Data | |
Clone Name | NT 3F5 |
Applications | IHC |
Recommended Dilution | Immunohistochemistryon Frozen Sections (See protocol below). |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Full length Human beta amyloid peptide 42 |
Specificity | This antibody recognizes the N-terminal sequence of beta Amyloid peptides. |
Formulation | 0.01M PBS, pH7.2 State: Aff - Purified State: Lyophilized purified IGg fraction |
Reconstitution Method | Double distillated water is recommended and to adjust the final concentration to 1.0 mg/ml. |
Purification | Affinity Chromatography on Protein G |
Conjugation | Unconjugated |
Storage | Store (in aliquots) at -20°C. |
Stability | Shelf life: one year from despatch. |
Background | Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase. |
Note | Protocol: Immunohistochemical Detection of AD tissues using Anti-Aβ42 antibodies Materials: |
Reference Data |
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