Benzo(a)pyrenediol-epoxide (BPDE) Mouse Monoclonal Antibody [Clone ID: 8E11]

CAT#: AM26348PU-N

Benzo(a)pyrenediol-epoxide (BPDE) mouse monoclonal antibody, clone 8E11, Purified

Specifications

Product Data

• Clone Name: 8E11
• Applications: ELISA
• Recommended Dilution: Immunoassays (detector).
  Useful for Immunopurification.
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: The monoclonal antibody 8E11 recognizes free BPDE and DNA adducts.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Conjugation: Unconjugated
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Background: A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.
• Synonyms: polycyclic aromatic hydrocarbon, PAH