LBP Mouse Monoclonal Antibody [Clone ID: 6G3]

CAT#: AM26277PU-N

LBP mouse monoclonal antibody, clone 6G3, Purified

Specifications

Product Data

• Clone Name: 6G3
• Applications: ELISA, FN, IP
• Recommended Dilution: Functional assays.
  ELISA both as coating and detector.
  Immunoprecipitation.
  Not useful for immunohistology neither for Western blot.
• Reactivities: Bovine, Canine, Goat, Human, Monkey, Porcine, Rabbit, Rat, Sheep
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: The monoclonal antibody 6G3 reacts highly specific with human natural and recombinant LBP. The antibody binds to LBP-LPS complexes whereas it inhibits the interaction of this complex with CD14.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Conjugation: Unconjugated
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Gene Name: lipopolysaccharide binding protein
• Database Link:
  NP_004130.2
  Entrez Gene 29469 RatEntrez Gene 3929 Human
  UniProt ID P18428
• Background: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
• Synonyms: Lipopolysaccharide-binding protein

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Toll-like receptor signaling pathway