Scarb1 Mouse Monoclonal Antibody [Clone ID: SR-BI]

CAT#: AM26164PU-N

Scarb1 mouse monoclonal antibody, clone SR-BI, Purified

Specifications

Product Data

• Clone Name: SR-BI
• Applications: FN, IHC
• Recommended Dilution: Flow cytometry (starting working dilution is 1:50).
  Immunohistochemistry on frozen sections.
  Functional assays.
• Reactivities: Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody reacts with rat class B scavenger receptor type I (SR-BI).
  It blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.
• Formulation: PBS
  State: Purified
  State: Liquid purified 0.2 µm filtered Ig fraction
  Preservative: 0.1% bovine serum albumin
• Concentration: lot specific
• Purification: Protein G
• Conjugation: Unconjugated
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Gene Name: scavenger receptor class B, member 1
• Database Link:
  Entrez Gene 25073 Rat
  UniProt ID P97943
• Background:

  Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family.
  SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.

• Synonyms: SRB1, SR-BI, CLA1, CLA-1, CD36L1