CD19 Mouse Monoclonal Antibody [Clone ID: 4G7]

CAT#: AM26006PU-N

CD19 mouse monoclonal antibody, clone 4G7, Purified

Product Images

Surface staining of human peripheral blood leukocytes with anti-human CD19 (4G7) purified.

Specifications

Product Data

• Clone Name: 4G7
• Applications: FC, IF
• Recommended Dilution: Flow Cytometry: 1 μg/ml.
  Immunocytochemistry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human CCL (chronic lymphocytic leukemia) cells
• Specificity: This antibody recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
• Formulation: PBS, pH~7.4 with 15 mM Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: lot specific
• Purification: Protein-A affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: CD19 molecule
• Database Link:
  Entrez Gene 930 Human
  UniProt ID P15391
• Background: CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
• Synonyms: Leu-12, B-cell marker

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiency