Progesterone Receptor (PGR) (C-term) Mouse Monoclonal Antibody [Clone ID: PR-6A]

CAT#: AM21049PU-N

Progesterone Receptor (PGR) (C-term) mouse monoclonal antibody, clone PR-6A, Aff - Purified

Product Images

Human Uterus, Paraffin Section stained with Progesterone receptor Antibody (Clone PR-6A)

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  Human Uterus, Paraffin Section stained with Progesterone receptor Antibody (Clone PR-6A)

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  Swnine Uterus, Frozen Section stained with Progesterone receptor Antibody (Clone PR-6A)

Specifications

Product Data

• Clone Name: PR-6A
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Frozen Sections: 2 µg/ml (1/100).
  Immunohistochemistry on Paraffin Sections: 20 µg/ml (1/10). Proteinase K pretreatment for antigen retrieval is recommended.
  Suggested Positive Control: Swine Uterus
• Reactivities: Chicken, Human, Rabbit
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Peptide A922-K933. Epitope: C-terminal region.
• Specificity: This antibody PR-6A recognizes the Human Progesterone Receptor in the C-terminal ligand-binding domain.
  Therefore, it recognizes isoforms A and B.
  Antigen Distribution: Nuclear hormone receptor, widely expressed.
• Formulation: Stock solution contains PBS, pH 7.2 with 5 mg/ml BSA as stabilizer and 0.01% Kathon as a preservative.
  State: Aff - Purified
  State: Lyophilized purified Ig fraction
• Reconstitution Method: Restore by adding 0.5 ml distilled water
• Concentration: 0.2 mg/ml (after reconstitution)
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage:

  Prior to reconstitution store at 2-8°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: progesterone receptor
• Database Link:
  Entrez Gene 5241 Human
  UniProt ID P06401
• Background: The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. Expressed by a single gene (chromosome 11q22), it has two main forms, A and B, that differ in their molecular weight. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PR determination provides supplementary information to ER, in predicting response to endocrine therapy as well as estimating survival. PR has proved superior to ER as a prognostic indicator in some studies.
  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
• Synonyms: PR, PGR, NR3C3

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Oocyte meiosis, Progesterone-mediated oocyte maturation