gamma Catenin (JUP) Mouse Monoclonal Antibody [Clone ID: CN-3]

CAT#: AM20592PU-N

gamma Catenin (JUP) mouse monoclonal antibody, clone CN-3, Aff - Purified

Product Images

Lane 1: MCF7 Whole Cell Lysate. Lane 2: HeLa Whole Cell Lysate. Lane 3: MM231 Whole Cell Lysate. Lane 4: HT1080 Whole Cell Lysate.

Specifications

Product Data

• Clone Name: CN-3
• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: Use at 0.1 - 0.5 μg/ml with the appropriate system to detect catenin Gamma (plakoglobin) in cells and tissues.
  Immunohistochemistry on Frozen Sections: Use at 0.5 - 1.0 μg/ml to detect Catenin Gamma (Plakoglobin) in Formalin/Acetone fixed tissues.
  Immunocytochemistry: Use at 1.0 μg/ml
  
• Reactivities: Chicken, Human, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Chicken plakoglobin.
• Specificity: Recognizes Catenin Gamma (Plakoglobin).
  No cross reactivity with other proteins.
• Formulation: 1.2% Sodium Acetate containing 2mg BSA and 0.01 mg Sodium Azide as preservative.
  State: Aff - Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with 1.2% Sodium Acetate or neutral PBS.
• Concentration: 0.1 mg/ml (after reconstitution with 1 ml PBS).
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: junction plakoglobin
• Database Link:
  Entrez Gene 81679 RatEntrez Gene 3728 Human
  UniProt ID P14923
• Background: Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
• Synonyms: Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer