Factor VIII (F8) Mouse Monoclonal Antibody [Clone ID: F8 2.2.9]

CAT#: AM20504PU-N

Factor VIII (F8) mouse monoclonal antibody, clone F8 2.2.9, Purified

Product Images

Human Placenta, Vessels (formalin-fixed, paraffin-embedded) stained with F8 antibody at 10 mg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Uterus, Vessels (formalin-fixed, paraffin-embedded) stained with F8 antibody at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: F8 2.2.9
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: F8 antibody was raised against purified human Factor VIII.
• Specificity: This antibody recognizes full-length Human Factor VIII (F8). Does not cross-react with von Willebrand factor.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein G chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store (in aliquots) at -20°C to -80°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: coagulation factor VIII
• Database Link:
  Entrez Gene 2157 Human
  UniProt ID P00451
• Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
• Synonyms: Procoagulant component, Antihemophilic factor, F8C, AHF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades