CD162 (SELPLG) Mouse Monoclonal Antibody [Clone ID: TC2]

CAT#: AM12002AC-N

CD162 (SELPLG) mouse monoclonal antibody, clone TC2, APC

Product Images

Surface staining of human peripheral blood cells with anti-human CD162 (clone TC2).

Specifications

Product Data

• Clone Name: TC2
• Applications: FC
• Recommended Dilution: The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension.
  The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human thymocytes
• Specificity: This antibody reacts with CD162, a 220 kDa type I integral membrane protein expressed as disulfide-linked homodimer (sialomucin family). CD162 is present on the most peripheral blood T lymphocytes, monocytes, granulocytes; it is also expressed on a subpopulation of B lymphocytes and CD34+ bone marrow cells.
• Formulation: PBS containing 15 mM Sodium Azide as preservative and 0.2% (w/v) high-grade protease free BSA as a stabilizing agent.
  Label: APC
  State: Liquid purified Ig fraction
  Label: Conjugated to Allophycocyanin
• Purification: Size-Exclusion Chromatography
• Conjugation: APC
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: selectin P ligand
• Database Link:
  Entrez Gene 6404 Human
  UniProt ID Q14242
• Background: CD162 (P-selectin glycoprotein ligand-1, PSGL-1) is a sialomucin constitutively expressed as a disulfide-linked homodimer of two 120 kDa subunits on the surface of circulating leukocytes. CD162 serves as a ligand for P- E- and L-selectin, with the highest affinity for P-selectin. It is thus involved in leukocyte rolling at the endothelial surfaces, prerequisite for firm leukocyte adhesion and subsequent transendothelial migration. CD162 also mediates leukocyte-platelet adhesion and interleukocyte contacts. Whereas serving as an adhession molecule on mature leukocytes, CD162 is a potent negative regulator of human hematopoietic progenitors.
• Synonyms: PSGL-1, Selectin P ligand, SELPLG

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)