Itgb7 Rat Monoclonal Antibody [Clone ID: DATK32]

CAT#: AM08074LE-N

Itgb7 rat monoclonal antibody, clone DATK32, Low Endotoxin

Specifications

Product Data

• Clone Name: DATK32
• Applications: FC, FN, IHC
• Recommended Dilution: Flow Cytometry. (Ref.1-4)
  Immunohistochemistry on Frozen Sections. (Ref.3)
  Induction of homotypic cellular aggregation. (Ref.1)
  Blockade of binding to cell adhesion molecules. (Ref.1)
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref.1)
• Specificity: This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7).
  It recognises a conformational epitope on the heterodimer.
• Formulation: PBS containing no preservatives.
  State: Low Endotoxin
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted in (aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin beta 7
• Database Link:
  Entrez Gene 16421 Mouse
  UniProt ID P26011
• Background: The lymphocyte Peyer’s patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4)
• Synonyms: Integrin alpha-4/beta-7, Integrin alpha 4, Integrin beta 7, ITGA4, ITGB7, LPAM1, CD49d, VLA-4